hsa-miR-26b

ncRNA information

ncRNA name

hsa-miR-26b

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

Pgp

Cancer information

Cancer name

Colorectal Cancer

Cancer site

Colon, Rectum, and Anus

Treatment information

Treatment type

Chemotherapy

Drug

5-Fluorouracil

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Down

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MiR-26b regulates 5-FU-resistance in human colorectal cancer via down-regulation of Pgp.

Tissue resource

adjacent normal tissues and colon tumor samples

human colon cancer cell lines HT-29

human colon cancer cell lines LOVO

human normal colorectal epithelial cell lines FHC

Experiment

qRT-PCR,Western blot


Institute

Changshu No.2 People's Hospital

American Type Culture Collection

Country

China

USA

Continent

Asia

North American