UCA1

ncRNA information

ncRNA name

UCA1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-582-5p

Cancer information

Cancer name

Bladder Cancer

Cancer site

Bladder

Treatment information

Treatment type

Chemotherapy

Drug

Rapamycin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

40

Male patients

30

Female patients

10

Age range and number

28(<50)+12(>=50)

Research information

PMID

Description

Long noncoding RNA UCA 1 targets miR-582-5p and contributes to the progression and drug resistance of bladder cancer cells through ATG7-mediated autophagy inhibition.

Tissue resource

bladder cancer tissues and adjacent normal specimens

human bladder cancer cell lines SV-HUC-1

human bladder cancer cell lines HT-1376

human bladder cancer cell lines T24

human bladder cancer cell lines J82

human bladder cancer cell lines 5637

human bladder cancer cell lines EJ

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the Renmin Hospital of Wuhan University

American Type Culture Collection

Country

China

USA

Continent

Asia

North American