Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
UCA1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-582-5p
Cancer name
Bladder Cancer
Cancer site
Bladder
Treatment type
Chemotherapy
Drug
Rapamycin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
40
Male patients
30
Female patients
10
Age range and number
28(<50)+12(>=50)
PMID
Description
Long noncoding RNA UCA 1 targets miR-582-5p and contributes to the progression and drug resistance of bladder cancer cells through ATG7-mediated autophagy inhibition.
Tissue resource
bladder cancer tissues and adjacent normal specimens
human bladder cancer cell lines SV-HUC-1
human bladder cancer cell lines HT-1376
human bladder cancer cell lines T24
human bladder cancer cell lines J82
human bladder cancer cell lines 5637
human bladder cancer cell lines EJ
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Renmin Hospital of Wuhan University
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.