Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa_circ_0001427
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-181c-5p/ARv7
Cancer name
Prostate Cancer
Cancer site
Prostate
Treatment type
Chemotherapy
Drug
Enzalutamide
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
CircRNA17 may function as suppressor to alter the Enz sensitivity and cell invasion in CRPC cells via altering the miR-181c-5p/ARv7 signaling and targeting this newly identified signaling may help in the development of a better therapy to further suppress the EnzR cell growth.
Tissue resource
clinical samples of benign prostatic hyperplasia and prostate cancer
human prostate cancer cell lines C4–2
human prostate cancer cell lines CWR22Rv1
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Tongji Hospital
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.