hsa_circ_0001427

ncRNA information

ncRNA name

hsa_circ_0001427

Specific or universal ncRNAs

Specific ncRNAs

Class

Circular RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

miR-181c-5p/ARv7

Cancer information

Cancer name

Prostate Cancer

Cancer site

Prostate

Treatment information

Treatment type

Chemotherapy

Drug

Enzalutamide

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

CircRNA17 may function as suppressor to alter the Enz sensitivity and cell invasion in CRPC cells via altering the miR-181c-5p/ARv7 signaling and targeting this newly identified signaling may help in the development of a better therapy to further suppress the EnzR cell growth.

Tissue resource

clinical samples of benign prostatic hyperplasia and prostate cancer

human prostate cancer cell lines C4–2

human prostate cancer cell lines CWR22Rv1

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the Tongji Hospital

American Type Culture Collection

Country

China

USA

Continent

Asia

North American