Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-122
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
SerpinB3
Cancer name
Hepatocellular Carcinoma
Cancer site
Liver
Treatment type
Chemotherapy
Drug
Sorafenib
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Anti-miR-122 transfection increased cell viability in sorafenib-treated Huh-7 cells, while miR-122 overexpression increased sorafenib sensitivity in treated cells, but not in those overexpressing SerpinB3. In conclusion, we demonstrated that miR-122 targets SerpinB3, and its low levels are associated with SerpinB3 positivity and a stem-like phenotype in HCC.
Tissue resource
hepatocellular carcinoma and cirrhotic tissues
hepatocellular carcinoma cell lines HepG2
hepatocellular carcinoma cell lines Hep3B
hepatocellular carcinoma cell lines Huh7
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
St.Orsola-Malpighi University Hospital, University of Padua
American Type Culture Collection
American Type Culture Collection
University of Bari
Country
Italy
Continent
Europe
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.