LINC00346

ncRNA information

ncRNA name

LINC00346

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

miR-188-3p/BRD4

Cancer information

Cancer name

Pancreatic Cancer

Cancer site

Pancreas

Treatment information

Treatment type

Chemotherapy

Drug

Gemcitabine

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

LINC00346 shows the ability to promote pancreatic cancer growth and gemcitabine resistance, which is in part mediated by antagonization of miR-188-3p and induction of BRD4. Targeting LINC00346 may improve gemcitabine-based therapeutic efficacy.

Tissue resource

human embryonic kidney cell lines HEK-293T

human pancreatic epithelial cell lines HPDE6c7

human pancreatic cancer cell lines PANC-1

human pancreatic cancer cell lines MIA PaCa-2

human pancreatic cancer cell lines Capan-1

human pancreatic cancer cell lines BxPC-3

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

Jiangnin Biotech. Co. Ltd.

American Type Culture Collection

Country

China

USA

Continent

Asia

North American