Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa_circ_0081143
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-646/CDK6
Cancer name
Gastric Cancer
Cancer site
Stomach
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Our study indicated a novel regulatory loop that hsa_circ_0081143/miR-646/CDK6 in GC progression. These data suggested that hsa_circ_0081143 might act as a potential novel therapeutic strategy for GC treatment.
Tissue resource
human gastric cancer tissues and adjacent non-tumor tissues
human gastric cancer cell lines SGC7901
human gastric cancer cell lines MGC803
human gastric epithelial cell lines GES1
human gastric cisplatin-resistant cell lines SGC7901/DDP
human gastric cisplatin-resistant cell lines MGC803/DDP
Experiment
qPCR,Western blot,Luciferase reporter assay
Institute
First Affiliated Hospital of XinXiang Medical University
Biochemistry and Cell Biology of the Chinese Academy of Sciences
Keygen Biotechnology Co., Ltd
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.