Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-222
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
ATG12/p27-mTOR
Cancer name
Multiple Myeloma
Cancer site
Multiple Myeloma
Treatment type
Chemotherapy
Drug
Dexamethasone
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Our findings demonstrated the crucial role of the miR-221/222-ATG12/p27-mTOR autophagy-regulatory in Dex resistance of MM, and they suggest potential prediction and treatment strategies for glucocorticoid resistance.
Tissue resource
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Country
Continent
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.