Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-221
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
ATG12/p27-mTOR
Cancer name
Multiple Myeloma
Cancer site
Multiple Myeloma
Treatment type
Chemotherapy
Drug
Dexamethasone
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Our findings demonstrated the crucial role of the miR-221/222-ATG12/p27-mTOR autophagy-regulatory in Dex resistance of MM, and they suggest potential prediction and treatment strategies for glucocorticoid resistance.
Tissue resource
primary plasma cells from healthy donors and multiple myeloma patient
primary plasma cells from healthy donors and multiple myeloma patient
human multiple myeloma cell lines MM.1S
human multiple myeloma cell lines MM.1R
human multiple myeloma cell lines RPMI-8226
human multiple myeloma cell lines U266
human multiple myeloma cell lines NCIH929
human multiple myeloma cell lines ARH-77
human multiple myeloma cell lines MR20
human multiple myeloma cell lines MM.1S
human multiple myeloma cell lines MM.1R
human multiple myeloma cell lines RPMI-8226
human multiple myeloma cell lines U266
human multiple myeloma cell lines NCIH929
human multiple myeloma cell lines ARH-77
human multiple myeloma cell lines MR20
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Huazhong University of Science and Technology
American Type Culture Collection
Harvard University
Country
China
USA
USA
Continent
Asia
North American
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.