Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
NEAT1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
Akt/mTOR signaling pathway
Cancer name
Non-Small Cell Lung Cancer
Cancer site
Lung
Treatment type
Chemotherapy
Drug
Paclitaxel
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
NEAT1 was associated with Akt/mTOR signaling pathway activation by increasing expression of p-Akt, p-mTOR, Bcl-2 and decreasing expression of Bax.
Tissue resource
human non-small cell lung cancer cell lines PC-9
human non-small cell lung cancer cell lines H1573
human non-small cell lung cancer cell lines H1299
human non-small cell lung cancer cell lines A549
normal human bronchial epithelial cell lines BE
Experiment
qRT-PCR,Western blot
Institute
the cell bank of Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.