NEAT1

ncRNA information

ncRNA name

NEAT1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

Akt/mTOR signaling pathway

Cancer information

Cancer name

Non-Small Cell Lung Cancer

Cancer site

Lung

Treatment information

Treatment type

Chemotherapy

Drug

Paclitaxel

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

NEAT1 was associated with Akt/mTOR signaling pathway activation by increasing expression of p-Akt, p-mTOR, Bcl-2 and decreasing expression of Bax.

Tissue resource

human non-small cell lung cancer cell lines PC-9

human non-small cell lung cancer cell lines H1573

human non-small cell lung cancer cell lines H1299

human non-small cell lung cancer cell lines A549

normal human bronchial epithelial cell lines BE

Experiment

qRT-PCR,Western blot


Institute

the cell bank of Chinese Academy of Sciences

Country

China

Continent

Asia