Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
HCG11
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-144-3p/UBE2D1
Cancer name
Gastric Cancer
Cancer site
qRT-PCR,Western blot,Dual-luciferase assay
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
22
Male patients
29
Female patients
26(<50)+25(>=50)
Age range and number
Not available
PMID
Description
HCG11 knockdown attenuated DDP resistance of GC cells through via miR-144-3p/UBE2D1 axis, affording a novel therapeutic strategy for GC
Tissue resource
gastric cancer tissues and paired adjacent non-tumor tissues
human gastric cancer cell lines AGS
human gastric cancer cell lines MKN45
human fetal gastric epithelial cell lines GES-1
Experiment
51
Institute
the First Affiliated Hospital, Heilongjiang University of Chinese Medicine
American Type Culture Collection
Country
China
United States
Continent
Asia
North Amercian
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.