Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
ADAMTS9-AS2
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-130a-5p/PTEN
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Tamoxifen
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Down
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
We found that ADAMTS9-AS2 is lowly expressed in BC tissues and drug-resistant BC cells. Low expression of ADAMTS9-AS2 inhibits PTEN expression and enhances tamoxifen resistance through targeting microRNA-130a-5p.
Tissue resource
breast cancer tissues and para-cancerous tissues
breast cancer cell lines MCF-7
breast cancer cell lines MCF-7R
Experiment
Western blot,Dual-luciferase reporter assay
Institute
the Affiliated Hospital of Jining Medical University
American Type Culture Collection
University of Michigan, Ann Arbor
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.