hsa-miR-155-3p

ncRNA information

ncRNA name

hsa-miR-155-3p

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

MYD88

Cancer information

Cancer name

Breast Cancer

Cancer site

Breast

Treatment information

Treatment type

Chemotherapy

Drug

Paclitaxel

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Down

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Down

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MiR-155-3p showed a negative effect on apoptosis, invasion and metastasis, reverses paclitaxel resistance by suppression of the corresponding target gene MYD88 in vitro and in vivo experiments.

Tissue resource

breast cancer tissues and paired adjacent normal breast tissue

normal human mammary epithelial cell lines MCF-10A

human breast cancer cell lines MCF-7

human breast cancer cell lines SKBR-3

human breast cancer cell lines MDA-MB-231

Experiment

qRT-PCR,Western blot,Dual-luciferase reporter assay


Institute

the First Affiliated Hospital of Bengbu Medical College

Chinese Academy of Sciences Shanghai ASTRI Cell Resource Center

Country

China

China

Continent

Asia

Asia