Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
SNHG16
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Prognosis/Treatment
Upstream regulatory factors
Not available
Downstream target
Not available
Cancer name
Hepatocellular Carcinoma
Cancer site
Liver
Treatment type
Chemotherapy
Drug
Sorafenib
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
61
Male patients
43
Female patients
18
Age range and number
31(<=55)+30(>55)
PMID
Description
Downregulation of SNHG16 inhibited proliferation, migration, invasion, and sorafenib resistance in hepatocellular carcinoma cell lines.
Tissue resource
fresh hepatocellular carcinoma tissues and adjacent non-cancerous samples
normal liver cell lines HL-7702
hepatocellular carcinoma cell lines SK-Hep-1
hepatocellular carcinoma cell lines Huh7
hepatocellular carcinoma cell lines Hep3B
hepatocellular carcinoma cell lines HepG2
Experiment
qRT-PCR
Institute
the First Affiliated Hospital of the Anhui Medical University
the Cell Bank of the Type Culture Collection, Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.