Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-206
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
MAP4K3
Cancer name
Papillary Thyroid Carcinoma
Cancer site
Thyroid
Treatment type
Chemotherapy
Drug
Euthyrox
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Down
ncRNA differential expression in
cancer
patients vs. healthy people
Down
Number of patients
23
Male patients
5
Female patients
18
Age range and number
Not available
PMID
Description
MiR-206 contributed to euthyrox resistance in PTC cells through blockage p38 and JNK signaling pathway by targeting MAP4K3, providing a potential therapeutic application for the treatment of patients with euthyrox-resistant PTC in the further.
Tissue resource
papillary thyroid carcinoma tissues
thyroid follicular epithelial cell lines Nthy-ori3-1
papillary thyroid carcinoma cell lines TPC-1
papillary thyroid carcinoma euthyrox-resistant cell lines TPC-1/euthyrox
Experiment
PCR,Western blot,Luciferase reporter assay
Institute
the Jiangsu Cancer Hospital
the Shanghai Cell Institute
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.