Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa_circ_0000199
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-198/PIK3R1
Cancer name
Gastric Cancer
Cancer site
Stomach
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
105
Male patients
80
Female patients
25
Age range and number
62(<60)+43(>=60)
PMID
Description
CircAKT3 plays an important role in the resistance of GC to CDDP. Thus, our results highlight the potential of circAKT3 as a therapeutic target for GC patients receiving CDDP therapy.
Tissue resource
gastric cancer tissues
gastric cancer cisplatin-sensitive cell lines SGC7901
gastric cancer cisplatin-sensitive cell lines BGC823
gastric cancer cisplatin-resistant cell lines SGC7901CDDP
gastric cancer cisplatin-resistant cell lines BGC823CDDP
Experiment
Western blot,Dual-luciferase reporter assay
Institute
the First Affiliated Hospital of Nanjing Medical University
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.