Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
DLEU1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-99b/HS3ST3B1
Cancer name
Bladder Cancer
Cancer site
Bladder
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Our study revealed a novel role for the DLEU1/miR-99b/HS3ST3B1 in regulating proliferation, invasion, and cisplatin resistance of BCA cells.
Tissue resource
bladder cancer and adjacent normal tissues
human bladder cancer cell lines T24
human bladder cancer cell lines SW780
primary normal human bladder epithelial cell lines
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Fourth Affiliated Hospital of China Medical University
the Shanghai Institute of Cell Biology
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.