Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
DANCR
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
mTOR/HIF-1Ī±
Cancer name
Gastric Cancer
Cancer site
Stomach
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Up
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
62
Male patients
32
Female patients
30
Age range and number
Not available
PMID
Description
Upregulation of DANCR can accelerate the MDR development of GC, which may become a potential target for treating GC with MDR.
Tissue resource
DDP-sensitive gastric cancer tissues and cases of cisplatin-resistant gastric cancer tissues
gastric cancer cell lines SGC7901
gastric cancer cell lines BGC823
Experiment
qRT-PCR,Western blot
Institute
the Yantai Yuhuangding Hospital
the Cell Bank, Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.