Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
SNHG15
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Prognosis/Treatment
Upstream regulatory factors
MYC
Downstream target
Not available
Cancer name
Colorectal Cancer
Cancer site
Colon, Rectum, and Anus
Treatment type
Chemotherapy
Drug
5-Fluorouracil
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
36
Male patients
17
Female patients
19
Age range and number
13(>=60)+23(<60)
PMID
Description
Moreover, knockdown of SNHG15 increases the sensitiveness of the cells to 5-FU, while its overexpression renders them more resistant to the chemotherapeutic drug
Tissue resource
colorectal cancer specimens and their adjacent normal tissues
human colorectal cancer cell lines DLD1
human colorectal cancer cell lines HCT 116
human colorectal cancer cell lines HT-29
human colorectal cancer cell lines LoVo
human colorectal cancer cell lines LS513
human colorectal cancer cell lines SW620
human colorectal cancer cell lines T84
Experiment
qRT-PCR,Western blot
Institute
the Imam-Reza Hospital
Country
Iran
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.