Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
LINC00221
Specific or universal ncRNAs
Specific ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Diagnosis/Treatment
Upstream regulatory factors
Not available
Downstream target
miR-519a
Cancer name
Non-Small Cell Lung Cancer
Cancer site
Lung
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Linc00221 promotes cisplatin resistance in NSCLC through the downstream miR-519a/ZBTB5 signaling , which could be used as a potential diagnostic and therapeutic target for clinical cisplatin-resistant NSCLC patients.
Tissue resource
non-small cell lung cancer tissues
normal bronchial epithelial cell lines HBE
lung adenocarcinoma cell lines H1299
lung adenocarcinoma cell lines A549
lung adenocarcinoma cell lines H1299/CR
lung adenocarcinoma cell lines A549/CR
lung adenocarcinoma cell lines SK-MES-1
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
Qingdao Municipal Hospital
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.