Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-552
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
SMAD2
Cancer name
Colorectal Cancer
Cancer site
Colon, Rectum, and Anus
Treatment type
Chemotherapy
Drug
5-Fluorouracil
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
97
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Our findings have revealed a critical role of miR-552/SMAD2 cascade in modulating cellular response to 5-FU chemotherapy. MiR-552 may act as an efficient mechanistic link synchronizing dMMR and 5-FU resistance in CRC.
Tissue resource
colorectal cancer tissues and adjacent normal tissues
colorectal cancer cell lines SW-480
colorectal cancer cell lines SW-620
colorectal cancer cell lines HT-116
normal colon epithelial cell lines CCD-18Co
Experiment
qRT-PCR,Western blot,Southern blot,Dual-luciferase reporter assay
Institute
the Second Affiliated Hospital of Xi'an Jiaotong University
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.