Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
ANGPTL1-3
Specific or universal ncRNAs
Specific ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-30a-3p
Cancer name
Multiple Myeloma
Cancer site
Multiple Myeloma
Treatment type
Chemotherapy
Drug
Bortezomib
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Knockdown of lnc-ANGPTL1-3 increased Btz sensitivity of MM cells. Following exploration revealed that lnc-ANGPTL1-3 competitively interacted with miR-30a-3p to c-Maf, a transcription factor which was reported to be associated with Btz resistance.
Tissue resource
bone marrow samples of multiple myeloma patients and healthy donors and Btz-resistant multiple myeloma patients
multiple myeloma cell lines NCI-H929
multiple myeloma cell lines RPMI-8226
multiple myeloma cell lines U266
multiple myeloma cell lines OPM2
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
the First Affiliated Hospital of Bengbu Medical University
Shanghai Institutes for Biological Sciences Cell Resource Center
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.