Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-221
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
PPP2R2A
Cancer name
Ovarian Carcinoma
Cancer site
Ovary
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Up
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Overexpression of miR-221 promoted OS cell invasion, migration, proliferation, and cisplatin resistance.
Tissue resource
human ovarian cancer specimens
human ovarian cancer cell lines OVCAR3
human ovarian cancer cell lines SKOV3
normal human ovarian epithelial cell lines IOSE
Experiment
qRT-PCR,Western blot
Institute
the Hunan Provincial Tumor Hospital/the Second XiangYa Hospital of Central South University
ScienCell Research Laboratories
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.