Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-126-3p
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
ADAM9/VEGF-A
Cancer name
Melanoma
Cancer site
Skin
Treatment type
Chemotherapy
Drug
Dabrafenib
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Up
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
ADAM9 knock-down in the resistant cells increased dabrafenib sensitivity, whereas miR-126-3p enforced expression or ADAM9 silencing in the drug-sensitive cells delayed the development of resistance.
Tissue resource
human melanoma cell lines A375
human melanoma cell lines SK-Mel28
Experiment
qRT-PCR,Western blot
Institute
European Collection of Cell Cultures
Country
UK
Continent
Europe
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.