hsa-miR-7

ncRNA information

ncRNA name

hsa-miR-7

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

REGĪ³

Cancer information

Cancer name

Breast Cancer

Cancer site

Breast

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Silencing CDR1as may inhibit the expression of REGĪ³ by removing the competitive inhibitory effect on miR-7 and thus enhancing the sensitivity of drug-resistant breast cancer cells.

Tissue resource

breast cancer tissue

breast cancer cell lines MCF-7

breast cancer cell lines SKBR-3

breast cancer cell lines MDA-MB-231

breast cancer cell lines MDAMB-468

breast cancer cell lines HCC-1937

normal breast epithelial cell lines MCF10A

Experiment

qRT-PCR,Western blot,Dual-Luciferase reporter assay


Institute

The Fifth People's Hospital of Wuxi

the Chinese Academy of Sciences Cell Bank

Country

China

Continent

Asia