Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-7
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
REGĪ³
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Silencing CDR1as may inhibit the expression of REGĪ³ by removing the competitive inhibitory effect on miR-7 and thus enhancing the sensitivity of drug-resistant breast cancer cells.
Tissue resource
breast cancer tissue
breast cancer cell lines MCF-7
breast cancer cell lines SKBR-3
breast cancer cell lines MDA-MB-231
breast cancer cell lines MDAMB-468
breast cancer cell lines HCC-1937
normal breast epithelial cell lines MCF10A
Experiment
qRT-PCR,Western blot,Dual-Luciferase reporter assay
Institute
The Fifth People's Hospital of Wuxi
the Chinese Academy of Sciences Cell Bank
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.