Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-1
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
Not available
Cancer name
Gastric Cancer
Cancer site
Stomach
Treatment type
Chemotherapy
Drug
Adriamycin/Vincristine
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Overexpression of sorcin could partially reverse the effect of miR-1 in MDR GC cells. The role of miR-1 in MDR GC cells makes it a potential therapeutic target for a successful clinical outcome.
Tissue resource
gastric cancer cell lines SGC7901
gastric cancer vincristine-resistant cell lines SGC7901/VCR
gastric cancer adriamycin-resistant cell lines SGC7901/ADM
Experiment
qRT-PCR,Western blot,Dual-Luciferase reporter assay
Institute
the Shanghai Institutes for Biological Sciences Cell Resource Center
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.