Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
HOXA11-AS
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-214-3p
Cancer name
Oral Squamous Cell Carcinoma
Cancer site
Lip, Oral Cavity
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
HOXA11-AS was identified to facilitate CDDP-resistance in OSCC and miR-214-3p/PIM1 was found to be the downstream target of HOXA11-AS.
Tissue resource
oral squamous cell carcinoma tumor tissues and normal adjacent squamous epithelium
normal human oral keratinocyte cell lines NHOK
oral squamous cell carcinoma cell lines TSCCA
oral squamous cell carcinoma cell lines CAL-27
oral squamous cell carcinoma cell lines SCC-9
oral squamous cell carcinoma cell lines Tca8113
Experiment
qRT-PCR,Luciferase reporter assay
Institute
The People's Hospital of Shanxi Province
the Cell Bank of Type Culture Collection of Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.