Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-591
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
FBP2
Cancer name
Hepatocellular Carcinoma
Cancer site
Liver
Treatment type
Chemotherapy
Drug
Cisplatin/Doxorubicin
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
65
Male patients
36
Female patients
29
Age range and number
Not available
PMID
Description
MiR-591 could suppress FBP2 expression by blocking the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin.
Tissue resource
hepatocellular carcinoma tissues and adjacent normal tissues
hepatocellular carcinoma cell lines HepG 2
hepatocellular carcinoma cell lines Hep3B
hepatocellular carcinoma cell lines SK-HE P1
hepatocellular carcinoma cell lines HUH7
human normal liver cell lines L02
Experiment
qRT-PCR,Western blot,Dual-Luciferase reporter assay
Institute
the Affiliated Hospital of Jining Medical University
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.