Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
SNHG1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-140-5p/Wnt/Ī²-catenin
Cancer name
Non-Small Cell Lung Cancer
Cancer site
Lung
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
SNHG1 knockdown ameliorated DDP resistance of NSCLC by regulating miR-140-5p/W-catenin pathway, providing a new potential therapeutic target for DDP-resistance NSCLC treatment.
Tissue resource
DDP-sensitive non-small cell lung cancer tissues and cisplatin-resistant non-small cell lung cancer tissues
human bronchial epithelial cell lines 16HBE
non-small cell lung cancer cell lines A549
non-small cell lung cancer cell lines H1299
Experiment
qRT-PCR,Western blot,Dual-Luciferase reporter assay
Institute
the Xi'an No.1 Hospital
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.