hsa-miR-200c

ncRNA information

ncRNA name

hsa-miR-200c

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

NER-ERCC3/4 signaling pathway

Cancer information

Cancer name

Gastric Cancer

Cancer site

Stomach

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Down

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Overexpression of miR-200c-3p may reverse drug resistance in the SGC7901/DDP GC cell line via downregulation of ERCC3 and ERCC4, which suggested this may be part of a mechanism involving the NER pathway.

Tissue resource

human gastric adenocarcinoma cisplatin-resistant cell lines SGC7901/DDP

human gastric adenocarcinoma cell lines SGC7901

Experiment

qRT-PCR,Western blot


Institute

Nanjing KeyGen Biotech Co., Ltd

Country

China

Continent

Asia