hsa-miR-200b

ncRNA information

ncRNA name

hsa-miR-200b

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

ARRDC3

Downstream target

Not available

Cancer information

Cancer name

Triple-Negative Breast Cancer

Cancer site

Breast

Treatment information

Treatment type

Chemotherapy

Drug

5-Fluorouracil

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MiR-200b played an essential role in mediating ARRDC3 dependent reversal of EMT phenotypes and chemo-resistance to DNA damaging agents in TNBC cells.

Tissue resource

breast cancer cells MCF7

breast cancer cells MDA-MB-468

breast cancer cells MDA-MB-231

breast cancer cells HCC-1937

breast cancer cells BT474

breast cancer cells BT549

Experiment

qRT-PCR,Western blot


Institute

American Type Culture Collection

Country

USA

Continent

North American