Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-200b
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
ARRDC3
Downstream target
Not available
Cancer name
Triple-Negative Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
5-Fluorouracil
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MiR-200b played an essential role in mediating ARRDC3 dependent reversal of EMT phenotypes and chemo-resistance to DNA damaging agents in TNBC cells.
Tissue resource
breast cancer cells MCF7
breast cancer cells MDA-MB-468
breast cancer cells MDA-MB-231
breast cancer cells HCC-1937
breast cancer cells BT474
breast cancer cells BT549
Experiment
qRT-PCR,Western blot
Institute
American Type Culture Collection
Country
USA
Continent
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.