hsa-miR-4262

ncRNA information

ncRNA name

hsa-miR-4262

Specific or universal ncRNAs

Specific ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

PTEN

Cancer information

Cancer name

Non-Small Cell Lung Cancer

Cancer site

Lung

Treatment information

Treatment type

Chemotherapy

Drug

Paclitaxel

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MiR-4262 enhances PTX resistance in NSCLC cells through targeting PTEN and activating the PI3 K/Akt signalling pathway. The inhibition of miR-4262 expression might be an improved treatment to overcome PTX resistance in NSCLC.

Tissue resource

non-small cell lung cancer specimens

non-small cell lung cancer cell lines A549

non-small cell lung cancer cell lines H1299

Experiment

qRT-PCR,Western blot,Dual-Luciferase reporter assay


Institute

the First Affiliated Hospital of Kunming Medical University

American Type Culture Collection

Country

China

USA

Continent

Asia

North American