H19

ncRNA information

ncRNA name

H19

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

SAHH/DNMT3B

Cancer information

Cancer name

Breast Cancer

Cancer site

Breast

Treatment information

Treatment type

Chemotherapy

Drug

Tamoxifen

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

H19 induces autophagy activation via the H19/SAHH/DNMT3B , which could contribute to tamoxifen resistance in breast cancer.

Tissue resource

tamoxifen-sensitive and tamoxifen-resistant breast cancer tissues

human breast cancer cell lines MCF7

Experiment

qRT-PCR,Western blot


Institute

Zhejiang University School of Medicine

American Type Culture Collection

Country

China

USA

Continent

Asia

North American