Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-16
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
14-3-3Ī·
Cancer name
Hepatocellular Carcinoma
Cancer site
Liver
Treatment type
Chemotherapy
Drug
Sorafenib
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MicroRNA-16 is a competent miRNA that reverses sorafenib resistance by targeting the 3'-UTR of 14-3-3Ī· and thereby inhibits 14-3-3Ī·/HIF-1Ī±/CSC properties.
Tissue resource
hepatocellular carcinoma tissues
hepatocellular carcinoma cell lines HuH7
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Nanjing Medical University
Institute of Biochemistry and Cell Biology
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.