BLACAT1

ncRNA information

ncRNA name

BLACAT1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

STAT3

Cancer information

Cancer name

Non-Small Cell Lung Cancer

Cancer site

Lung

Treatment information

Treatment type

Chemotherapy

Drug

Afatinib

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Knockdown of BLACAT1 reversed the resistance of afatinib to NSCLC cells by modulating STAT3 signaling. The results provided a potential strategy for afatinib-resistant NSCLC by targeting BLACAT1.

Tissue resource

non-small cell lung cancer cell lines Calu3

non-small cell lung cancer cell lines H1975

Experiment

qRT-PCR,Western blot


Institute

American Type Culture Collection

Country

USA

Continent

North American