GAS5

ncRNA information

ncRNA name

GAS5

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

GAS5-E2F4-PARP1-MAPK

Cancer information

Cancer name

Ovarian Cancer

Cancer site

Ovary

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Compared with sensitive cell lines, GAS5 was also low expressed in DDP resistant OC cell lines, and over-expression of GAS5 significantly enhanced the sensitivity of OC cells to DDP in vivo and in vitro.

Tissue resource

epithelial ovarian carcinoma tissues and normal ovarian tissues

human ovarian cancer cell lines HEY

human ovarian cancer cell lines A2780

human ovarian cancer cell lines A2780/DDP

human ovarian cancer cell lines HO8910

human ovarian cancer cell lines HO8910PM

human ovarian cancer cell lines SKOV3

human ovarian cancer cisplatin-resistant cell lines SKOV3/DDP

normal human ovarian epithelial cell lines IOSE

Experiment

qRT-PCR,Western blot


Institute

Renji hospital, School of Medicine, Shanghai Jiao Tong University

Country

China

Continent

Asia