Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
GAS5
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
GAS5-E2F4-PARP1-MAPK
Cancer name
Ovarian Cancer
Cancer site
Ovary
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Compared with sensitive cell lines, GAS5 was also low expressed in DDP resistant OC cell lines, and over-expression of GAS5 significantly enhanced the sensitivity of OC cells to DDP in vivo and in vitro.
Tissue resource
epithelial ovarian carcinoma tissues and normal ovarian tissues
human ovarian cancer cell lines HEY
human ovarian cancer cell lines A2780
human ovarian cancer cell lines A2780/DDP
human ovarian cancer cell lines HO8910
human ovarian cancer cell lines HO8910PM
human ovarian cancer cell lines SKOV3
human ovarian cancer cisplatin-resistant cell lines SKOV3/DDP
normal human ovarian epithelial cell lines IOSE
Experiment
qRT-PCR,Western blot
Institute
Renji hospital, School of Medicine, Shanghai Jiao Tong University
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.