Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-301a
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
TCEAL7
Cancer name
Glioma
Cancer site
Brain, Central Nervous System
Treatment type
Radiotherapy
Impact of wild-type ncRNA on radiotherapy resistance
Up
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Here we show that exomiR-301a, which is characteristically expressed and secreted by hypoxic glioma cells, is a potent regulator of Wnt/b-catenin and then depresses radiation sensitivity through targeting anti-oncogene TCEAL7.
Tissue resource
pilocyticastrocytomas,diffuse astrocytomas,anaplasia astrocytomas and primary GBMs
Experiment
Luciferase reporter assay
Institute
the Affiliated Hospital of Xiangnan University, the National Cancer Center/Cancer Hospital & Shenzhen Hospital, the PLA Airforce General Hospital
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.