hsa_circ_0001839

ncRNA information

ncRNA name

hsa_circ_0001839

Specific or universal ncRNAs

Specific ncRNAs

Class

Circular RNA

Biomarker

Yes

Biomarker application

Diagnosis/Treatment

Upstream regulatory factors

Not available

Downstream target

miR-548p/PBLD

Cancer information

Cancer name

Breast Cancer

Cancer site

Breast

Treatment information

Treatment type

Chemotherapy

Drug

Doxorubicin

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Down

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Our data indicate that circKDM4C might have considerable potential as a prognostic biomarker in breast cancer, and support the notion that therapeutic targeting of circKDM4C/miR-548p/PBLD may be a promising treatment approach for breast cancer patients.

Tissue resource

breast cancer tissues tumor and normal tissues

breast cancer cell lines MDA-MB-231

breast cancer cell lines MDA-MB-468

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the Qilu Hospital of Shandong University

American Type Culture Collection

Country

China

USA

Continent

Asia

North American