Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa_circ_0001839
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
Yes
Biomarker application
Diagnosis/Treatment
Upstream regulatory factors
Not available
Downstream target
miR-548p/PBLD
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Doxorubicin
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Down
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Our data indicate that circKDM4C might have considerable potential as a prognostic biomarker in breast cancer, and support the notion that therapeutic targeting of circKDM4C/miR-548p/PBLD may be a promising treatment approach for breast cancer patients.
Tissue resource
breast cancer tissues tumor and normal tissues
breast cancer cell lines MDA-MB-231
breast cancer cell lines MDA-MB-468
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Qilu Hospital of Shandong University
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.