LINC01198

ncRNA information

ncRNA name

LINC01198

Specific or universal ncRNAs

Specific ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Upstream regulatory factors

Not available

Downstream target

NEDD4-1/PTEN

Cancer information

Cancer name

Glioma

Cancer site

Brain, Central Nervous System

Treatment information

Treatment type

Chemotherapy

Drug

Temozolomide

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Up

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

40

Male patients

22

Female patients

18

Age range and number

Not available

Research information

PMID

Description

We showed that LINC01198 exerted its oncogenic activities by enhancing the NEDD4-1-dependent repression of PTEN.

Tissue resource

glioma tissues and adjacent tissues

human glioma cell lines U87

human glioma cell lines U251

human glioma cell lines SHG-44

human glioma cell lines SNB-19

human glioma cell lines LN229

human glioma cell lines T98G

Experiment

qRT-PCR,Western blot


Institute

the Renji Hospital

American Type Culture Collection

Country

China

USA

Continent

Asia

North American