HIF1A-AS2

ncRNA information

ncRNA name

HIF1A-AS2

Specific or universal ncRNAs

Specific ncRNAs

Class

Long noncoding RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-146b-5p/IL-6/STAT3

Cancer information

Cancer name

Lung Adenocarcinoma

Cancer site

qRT-PCR,Western blot

Treatment information

Treatment type

Chemotherapy

Drug

Osimertinib

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Up

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

HIF1A-AS2 induces osimertinib resistance in lung adenocarcinoma patients by regulating the miR-146b-5p/IL-6/STAT3 axis

Tissue resource

lung adenocarcinoma tissues and paired adjacent non-tumor tissues

human lung adenocarcinoma cell lines PC9

human lung adenocarcinoma cell lines A549

human lung adenocarcinoma cell lines HCC827

human lung adenocarcinoma cell lines H1975

human lung adenocarcinoma cell lines HBE

Experiment

None


Institute

the Department of Thoracic Surgery, Peking University Cancer Hospital

Peking University Cancer Hospital

Country

China

China

Continent

Asia

Asia