Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
HIF1A-AS2
Specific or universal ncRNAs
Specific ncRNAs
Class
Long noncoding RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-146b-5p/IL-6/STAT3
Cancer name
Lung Adenocarcinoma
Cancer site
qRT-PCR,Western blot
Treatment type
Chemotherapy
Drug
Osimertinib
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
Up
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
HIF1A-AS2 induces osimertinib resistance in lung adenocarcinoma patients by regulating the miR-146b-5p/IL-6/STAT3 axis
Tissue resource
lung adenocarcinoma tissues and paired adjacent non-tumor tissues
human lung adenocarcinoma cell lines PC9
human lung adenocarcinoma cell lines A549
human lung adenocarcinoma cell lines HCC827
human lung adenocarcinoma cell lines H1975
human lung adenocarcinoma cell lines HBE
Experiment
None
Institute
the Department of Thoracic Surgery, Peking University Cancer Hospital
Peking University Cancer Hospital
Country
China
China
Continent
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.