PCAT-1

ncRNA information

ncRNA name

PCAT-1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

EZH2/PTEN

Cancer information

Cancer name

Gastric Cancer

Cancer site

Stomach

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

PCAT-1 led to cisplatin resistance in GC cells through epigenetically suppressing PTEN expression, providing a novel therapeutic strategy for GC patients with chemoresistance.

Tissue resource

gastric cancer tumor and adjacent normal tissues

human fetal gastric epithelial cell lines GES-1

human gastric cancer cell lines BGC823

human gastric cancer cell lines SGC7901

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

Huaihe Hospital of Henan University

American Type Culture Collection

Country

China

USA

Continent

Asia

North American