hsa_circ_0001946

ncRNA information

ncRNA name

hsa_circ_0001946

Specific or universal ncRNAs

Universal ncRNAs

Class

Circular RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-1270/SCAI

Cancer information

Cancer name

Ovarian Cancer

Cancer site

Ovary

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Our study demonstrated that Cdr1as sensitizes ovarian cancer to cisplatin by regulating the miR-1270/SCAI signaling pathway.

Tissue resource

human ovarian cancer cell lines A2780

human ovarian cancer cell lines SKOV-3

normal ovarian epithelial cell line IOSE-80

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

American Type Culture Collection

Country

USA

Continent

North American