NEAT1

ncRNA information

ncRNA name

NEAT1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

miR-9-5p/SPAG9

Cancer information

Cancer name

Anaplastic Thyroid Carcinoma

Cancer site

Thyroid

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

26

Male patients

8

Female patients

18

Age range and number

10(<60)+16(>=60)

Research information

PMID

Description

NEAT1 silencing ameliorated DDP-resistance of ATC, at least in part by reducing miR-9-5p sponging and regulating SPAG5 expression.

Tissue resource

tumor tissues and adjacent non-tumor thyroid tissues

anaplastic thyroid carcinoma cell lines SW1736

anaplastic thyroid carcinoma cell lines 8505C

human embryonic kidney cell lines HEK-293T

Experiment

qRT-PCR,Western blot


Institute

Henan Provincial People's Hospital

BeNa Culture Collection

American Type Culture Collection

Country

China

USA

Continent

Asia

North American