Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
NEAT1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-9-5p/SPAG9
Cancer name
Anaplastic Thyroid Carcinoma
Cancer site
Thyroid
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
26
Male patients
8
Female patients
18
Age range and number
10(<60)+16(>=60)
PMID
Description
NEAT1 silencing ameliorated DDP-resistance of ATC, at least in part by reducing miR-9-5p sponging and regulating SPAG5 expression.
Tissue resource
tumor tissues and adjacent non-tumor thyroid tissues
anaplastic thyroid carcinoma cell lines SW1736
anaplastic thyroid carcinoma cell lines 8505C
human embryonic kidney cell lines HEK-293T
Experiment
qRT-PCR,Western blot
Institute
Henan Provincial People's Hospital
BeNa Culture Collection
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.