Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa_circ_0035483
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
hsa-miR-335
Cancer name
Renal Cancer
Cancer site
Kidney
Treatment type
Chemotherapy
Drug
Gemcitabine
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Hsa_circ_0035483 promotes autophagy and tumor growth and enhances gemcitabine resistance in RCC by regulating hsa-miR-335/CCNB1, and silenced hsa_circ_0035483 can enhance gemcitabine sensitivity in vivo.
Tissue resource
kidney cancer tissues and adjacent normal tissues
Experiment
PCR,Western blot,Luciferase reporter assay
Institute
the First Affiliated Hospital of Zhengzhou University
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.