Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
LINC00957
Specific or universal ncRNAs
Specific ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Diagnosis/Treatment
Upstream regulatory factors
Not available
Downstream target
P-gP
Cancer name
Colorectal Cancer
Cancer site
Colon, Rectum, and Anus
Treatment type
Chemotherapy
Drug
5-Fluorouracil
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Mechanically, inhibition of LINC00957 expression reversed 5-FU resistance by down-regulating P-gP.
Tissue resource
colorectal cancer tissues and adjacent normal tissues
human colorectal cancer cell lines HCT8
human colorectal cancer cell lines SW480
human colorectal cancer cell lines SW620
human colorectal cancer cell lines LOVO
human colorectal cancer cell lines HCT116
normal human colon epithelial cell lines NCM460
human colorectal cancer 5-Fu-resistant cell lines HCT-8/5-Fu
Experiment
qRT-PCR,Western blot
Institute
the Affiliated Hospital of Jiangnan University
Nanjing Musai Bio-Tech Co, Ltd
Keygen Biotech Co. Ltd
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.