TUG1

ncRNA information

ncRNA name

TUG1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-197-3p

Cancer information

Cancer name

Colorectal Cancer

Cancer site

Colon, Rectum, and Anus

Treatment information

Treatment type

Chemotherapy

Drug

5-Fluorouracil

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

TUG1 knockdown re-sensitized the 5-Fu resistance in colorectal cancer cells, which were 5-Fu-resistant colorectal cell line.

Tissue resource

colorectal cancer tissues and para-tumor tissues

colorectal cancer 5-FU-resistant cell lines HCT8Fu

colorectal cancer 5-FU-sensitive cell lines HCT8

colorectal cancer cell lines HCT116

colorectal cancer cell lines SW1116

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the Second Affiliated Hospital of Harbin Medical University

Shanghai Meixuan Corporation

American Type Culture Collection

Country

China

USA

Continent

Asia

North American