FOXD2-AS1

ncRNA information

ncRNA name

FOXD2-AS1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

miR-185-5p/SIXI

Cancer information

Cancer name

Non-Small Cell Lung Cancer

Cancer site

Lung

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

FOXD2-AS1/miR185-5p/SIX1 regulates the progression and chemosensitivity of DDP-resistant NSCLC, suggesting a potential therapeutic target for cisplatin-resistant NSCLC patients.

Tissue resource

fresh non-small cell lung cancer tissue samples

non-small cell lung cancer cell lines A549

non-small cell lung cancer cell lines H1299

non-small cell lung cancer cisplatin-resistant cell lines A549/DDP

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the Second Affiliated Hospital of Xi'an Medical University

the Cell Bank of the Chinese Academy of Sciences

American Type Culture Collection

Country

China

USA

Continent

Asia

North American