Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
CCAT1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-143/PLK1/BUBR1
Cancer name
Esophageal Cancer
Cancer site
Esophagus
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
We discovered a novel mechanism by which CCAT1 promotes cell proliferation and enhances drug resistance by regulating the miR-143/PLK1/BUBR1 signaling both in vitro and in vivo.
Tissue resource
esophageal squamous cell carcinoma cell lines TE-1
esophageal squamous cell carcinoma cell lines ECA-109
esophageal squamous cell carcinoma cell lines KYSE-140
esophageal squamous cell carcinoma cell lines KYSE-70
esophageal squamous cell carcinoma cell lines KYSE-150
esophageal squamous cell carcinoma cell lines KYSE-450
Experiment
qRT-PCR,Western blot
Institute
the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.