Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
FOXD2-AS1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-195/Akt/mTOR
Cancer name
Esophageal Squamous Cell Carcinoma
Cancer site
Esophagus
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Up
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
20
Male patients
15
Female patients
5
Age range and number
Not available
PMID
Description
In an in vitro assay, knockdown of FOXD2-AS1 noticeably inhibited cell invasion and growth, triggered cell death, and repressed the stimulation of the Akt/mTOR in cisplatin-resistant ESCC cells.
Tissue resource
tumor specimens and matched adjacent nonmalignant tissues
human esophageal squamous cell carcinoma cell lines TE-1
normal esophageal epithelial cell lines HEEpic
pairs of matched esophageal squamous cell carcinoma specimens and surrounding normal tissues
human esophageal squamous cell carcinoma cell lines TE-1
normal esophageal epithelial cell lines HEEpic
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Taihe Hospital Affiliated to Hubei University of Medicine
the Chinese Academy of Sciences Cell Bank
American Type Culture Collection
Taihe Hospital Affiliated to Hubei University of Medicine
Chinese Academy of Science cell bank
American Type Culture Collection
Country
China
USA
China
China
United States
Continent
Asia
North American
Asia
Asia
North Amercian
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.