FOXD2-AS1

ncRNA information

ncRNA name

FOXD2-AS1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-195/Akt/mTOR

Cancer information

Cancer name

Esophageal Squamous Cell Carcinoma

Cancer site

Esophagus

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Up

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

20

Male patients

15

Female patients

5

Age range and number

Not available

Research information

PMID

Description

In an in vitro assay, knockdown of FOXD2-AS1 noticeably inhibited cell invasion and growth, triggered cell death, and repressed the stimulation of the Akt/mTOR in cisplatin-resistant ESCC cells.

Tissue resource

tumor specimens and matched adjacent nonmalignant tissues

human esophageal squamous cell carcinoma cell lines TE-1

normal esophageal epithelial cell lines HEEpic

pairs of matched esophageal squamous cell carcinoma specimens and surrounding normal tissues

human esophageal squamous cell carcinoma cell lines TE-1

normal esophageal epithelial cell lines HEEpic

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

Taihe Hospital Affiliated to Hubei University of Medicine

the Chinese Academy of Sciences Cell Bank

American Type Culture Collection

Taihe Hospital Affiliated to Hubei University of Medicine

Chinese Academy of Science cell bank

American Type Culture Collection

Country

China

USA

China

China

United States

Continent

Asia

North American

Asia

Asia

North Amercian