Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-296-5p
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Prognosis
Upstream regulatory factors
Not available
Downstream target
Bcl-2
Cancer name
Pancreatic Cancer
Cancer site
Pancreas
Treatment type
Chemotherapy
Drug
5-Fluorouracil/Gemcitabine
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
13
Male patients
6
Female patients
7
Age range and number
Not available
PMID
Description
MiR-296-5p is a useful biomarker for a poor prognosis in patients with PDAC, and that the miR-296-5p/BOK signaling plays an important role in cell invasion, drug resistance, and EMT in PDACs.
Tissue resource
pancreatic tumors
human pancreatic cancer cell lines PANC-1
human pancreatic cancer cell lines MIA PaCa-2
human pancreatic cancer cell lines PK-1
human pancreatic cancer cell lines PK-8
human pancreatic cancer cell lines PK-45H
Experiment
qRT-PCR,Western blot
Institute
Tokushima University Hospital
American Type Culture Collection
RIKEN Cell Bank
Country
Japan
USA
Japan
Continent
Asia
North American
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.