hsa-miR-296-5p

ncRNA information

ncRNA name

hsa-miR-296-5p

Specific or universal ncRNAs

Specific ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Prognosis

Upstream regulatory factors

Not available

Downstream target

Bcl-2

Cancer information

Cancer name

Pancreatic Cancer

Cancer site

Pancreas

Treatment information

Treatment type

Chemotherapy

Drug

5-Fluorouracil/Gemcitabine

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

13

Male patients

6

Female patients

7

Age range and number

Not available

Research information

PMID

Description

MiR-296-5p is a useful biomarker for a poor prognosis in patients with PDAC, and that the miR-296-5p/BOK signaling plays an important role in cell invasion, drug resistance, and EMT in PDACs.

Tissue resource

pancreatic tumors

human pancreatic cancer cell lines PANC-1

human pancreatic cancer cell lines MIA PaCa-2

human pancreatic cancer cell lines PK-1

human pancreatic cancer cell lines PK-8

human pancreatic cancer cell lines PK-45H

Experiment

qRT-PCR,Western blot


Institute

Tokushima University Hospital

American Type Culture Collection

RIKEN Cell Bank

Country

Japan

USA

Japan

Continent

Asia

North American

Asia