hsa-miR-873

ncRNA information

ncRNA name

hsa-miR-873

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

ZEB1

Cancer information

Cancer name

Triple-Negative Breast Cancer

Cancer site

Breast

Treatment information

Treatment type

Chemotherapy

Drug

Gemcitabine

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Up

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

The decrease of miR-873 promoted the development of gemcitabine resistance in TNBC via elevation of ZEB1 expression, which indicated that miR-873 may be a promising predictor for gemcitabine sensitivity in patients with TNBC.

Tissue resource

human embryonic kidney cell lines HEK-293T

human triple-negative breast cancer cell lines MDA-MB-231

human triple-negative breast cancer cell lines BT549

Experiment

qRT-PCR,Western blot,Dual-Luciferase reporter assay


Institute

American Type Culture Collection

Country

USA

Continent

North American